Are you due to have a laparoscopy for symptoms suggestive of endometriosis?
Many women with endometriosis are treated surgically but symptoms can recur in just under half of them. Clinicians are uncertain about how best to prevent this.
32 hospitals throughout the UK have joined a large national clinical trial to find out if long acting progestogen treatment (either Mirena Coil® or Depo-Provera® ) is more effective compared to the oral contraceptive pill in preventing the recurrence of symptoms and improving quality of life.
The target population is women of reproductive age with laparoscopically diagnosed endometriosis, who have undergone conservative surgery for alleviation of pelvic pain, and who have no contraindications to any of the proposed hormonal treatments. The PRE-EMPT trial will be discussed with women when they are scheduled for laparoscopic surgery.
The treatments offered in PRE-EMPT are:-
Mirena® coil
progestogens
Combined oral Contraceptive
Further details of these can be found at https://www.endometriosis-uk.org/hormones
You may be eligible to take part in the PRE-EMPT trial if you
- Are aged between 16-45 years
- Have no immediate plans to conceive
- Are scheduled to have laparoscopy with concurrent surgery for pelvic pain associated with endometriosis
- Willing to be randomised to either:
- long acting progestogen treatment (you can choose between Mirena® or Depo-provera®
or
- The combined oral contraceptive
What the trial involves
We will collect information on your pain, physical and emotional wellbeing at the beginning of the study. A similar questionnaire will then be sent to you at home at 6 months, then 1, 2 and 3 years after treatment. The questions are designed to find out if there are any improvements or changes in your symptoms following treatment
Which hospitals are taking part
|
Aberdeen Royal Infirmary |
QMC - Nottingham Treatment Centre |
|
Addenbrooke's (Cambridge) |
Royal Albert Edward Infirmary |
|
Arrowe Park Hospital |
Royal Berkshire Hospital |
|
Basingstoke & N.Hampshire |
Royal Infirmary of Edinburgh |
|
Birmingham Women's Hospital |
Royal Preston Hospital |
|
Chelsea and Westminster Hospital |
Southend University Hospital |
|
Chesterfield Royal Hospital |
St Mary's, Manchester |
|
Cumberland Infirmary & W. Cumberland Hospital |
St Peter's Hospital |
|
Furness General Hospital |
St Richard's Hospital, Chichester |
|
James Cook University Hospital |
Stoke Mandeville Hospital |
|
John Radcliffe Hospital |
The Royal Victoria Infirmary (Newcastle) |
|
Kings Mill Hospital |
University College London Hospital |
|
Liverpool Women's Hospital |
University Hospital Crosshouse |
|
Milton Keynes Hospital |
University Hospital of North Durham |
|
Peterborough City Hospital |
University Hospital of North Tees |
|
Princess of Wales (Wales) |
Yeovil District Hospital |
How to get involved
For more information about the hospitals recruiting and how to get in touch with us please contact
Laura Gennard
Senior Trial Coordinator
Tel: +44 (0)121 415 9109
Fax: +44 (0)121 415 9136
Email: d.a.m.farrell@bham.ac.uk
Web: pre-empt@trials.bham.ac.uk
Birmingham Clinical Trials Unit (BCTU)
Institute of Applied Health Research
Public Health Building
University of Birmingham
Edgbaston
Birmingham
B15 2TT
